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Department微细加工光学技术国家重点实验室(开放室)
Hydrothermal synthesis of N,S co-doped carbon nanodots for highly selective detection of living cancer cells
Cheng, Wenbo1,2,3; Xu, Jun4; Guo, Zhenzhen2; Yang, Dawei2; Chen, Xifeng2,5; Yan, Wei1; Miao, Peng2
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
Volume6Issue:36Pages:5775-5780
2018-09-28
Language英语
ISSN2050-750X
DOI10.1039/c8tb01271g
Indexed BySCI ; Ei
WOS IDWOS:000448413200012
EI Accession Number20183905863126
SubtypeJ
AbstractThis study presents a facile synthesis method for the preparation of positively charged N,S co-doped carbon nanodots with excellent optical properties, and it develops a selective method for fluorescent detection of living cancer cells. The specific recognition is due to the application of an aptamer sequence, which shows high affinity and specificity to target cells. The aptamer is firstly labeled with BHQ and wraps around the carbon nanodots, then it finally quenches the fluorescence emission of the carbon nanodots. For the sensitive and selective analysis of target cells, the cells are simply mixed with the carbon nanodot-aptamer nanoconjugates, which are then centrifuged at a low speed. The recognition reaction between aptamer and target cells releases the quencher from the surface of the carbon nanodots and the centrifugation process enables the recovery of fluorescence intensity of the suspension, which reflects the level of initial cancer cells. The developed method is simple, highly selective and cost-effective, thus, it may be further exploited in clinical applications in the future.
KeywordCarbon Cost effectiveness Cytology Diseases Fluorescence Hydrothermal synthesis Molecular biology Nanodots Optical properties
WOS KeywordBREAST-CANCER ; PHOTOLUMINESCENCE MECHANISM ; COLORIMETRIC DETECTION ; FACILE SYNTHESIS ; QUANTUM DOTS ; FOLIC-ACID ; NANOPARTICLES ; CYTOSENSOR ; STRATEGY ; NITROGEN
EI KeywordsCarbon ; Cost effectiveness ; Cytology ; Diseases ; Fluorescence ; Hydrothermal synthesis ; Molecular biology ; Nanodots ; Optical properties
EI Classification Number461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 741.1 Light/Optics ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 911.2 Industrial Economics
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Document Type期刊论文
Identifierhttp://ir.ioe.ac.cn/handle/181551/9294
Collection微细加工光学技术国家重点实验室(开放室)
Affiliation1.State Key Lab of Optical Technologies On Nano-fabrication and Micro-engineering, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu; 610209, China;
2.Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou; 215163, China;
3.University of Chinese Academy of Sciences, Beijing; 100049, China;
4.Suzhou Blood Center, Suzhou; 215006, China;
5.Tianjin Guoke Jiaye Medical Technology Development Co., LTD, Tianjin; 300399, China
Recommended Citation
GB/T 7714
Cheng, Wenbo,Xu, Jun,Guo, Zhenzhen,et al. Hydrothermal synthesis of N,S co-doped carbon nanodots for highly selective detection of living cancer cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(36):5775-5780.
APA Cheng, Wenbo.,Xu, Jun.,Guo, Zhenzhen.,Yang, Dawei.,Chen, Xifeng.,...&Miao, Peng.(2018).Hydrothermal synthesis of N,S co-doped carbon nanodots for highly selective detection of living cancer cells.JOURNAL OF MATERIALS CHEMISTRY B,6(36),5775-5780.
MLA Cheng, Wenbo,et al."Hydrothermal synthesis of N,S co-doped carbon nanodots for highly selective detection of living cancer cells".JOURNAL OF MATERIALS CHEMISTRY B 6.36(2018):5775-5780.
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