| Department | 薄膜光学技术研究室（十一室） |
| Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection | |
| Zhou, Sheng1,2; Han, Yanling1; Li, Bincheng1,3 | |
| Source Publication | APPLIED PHYSICS B-LASERS AND OPTICS
 |
| Volume | 124Issue:2Pages:27 |
| 2018-02-01 | |
| Language | 英语 |
| ISSN | 0946-2171 |
| DOI | 10.1007/s00340-018-6898-9 |
| Indexed By | SCI ; Ei |
| WOS ID | WOS:000424352000005 |
| EI Accession Number | 20180504682919 |
| Subtype | J |
| Abstract | Nitric oxide (NO) in exhaled breath has gained increasing interest in recent years mainly driven by the clinical need to monitor inflammatory status in respiratory disorders, such as asthma and other pulmonary conditions. Mid-infrared cavity ring-down spectroscopy (CRDS) using an external cavity, widely tunable continuous-wave quantum cascade laser operating at 5.3 mu m was employed for NO detection. The detection pressure was reduced in steps to improve the sensitivity, and the optimal pressure was determined to be 15 kPa based on the fitting residual analysis of measured absorption spectra. A detection limit (1 sigma, or one time of standard deviation) of 0.41 ppb was experimentally achieved for NO detection in human breath under the optimized condition in a total of 60 s acquisition time (2 s per data point). Diurnal measurement session was conducted for exhaled NO. The experimental results indicated that mid-infrared CRDS technique has great potential for various applications in health diagnosis. |
| Keyword | Absorption spectroscopy Band structure Infrared devices Nitric oxide Quantum cascade lasers |
| WOS Keyword | NITRIC-OXIDE ; BREATH ; LASER ; AIR ; CHILDREN ; SENSOR ; GAS |
| EI Keywords | Absorption spectroscopy ; Band structure ; Infrared devices ; Nitric oxide ; Quantum cascade lasers |
| EI Classification Number | 744.1 Lasers, General ; 804.2 Inorganic Compounds ; 933 Solid State Physics ; 941.4 Optical Variables Measurements |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ioe.ac.cn/handle/181551/9259 |
| Collection | 薄膜光学技术研究室（十一室） |
| Affiliation | 1.Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu; Shuangliu; 610209, China; 2.Graduate University of Chinese Academy of Sciences, Beijing; 100049, China; 3.School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu; 610054, China |
| Recommended Citation GB/T 7714 | Zhou, Sheng,Han, Yanling,Li, Bincheng. Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection[J]. APPLIED PHYSICS B-LASERS AND OPTICS,2018,124(2):27. |
| APA | Zhou, Sheng,Han, Yanling,&Li, Bincheng.(2018).Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection.APPLIED PHYSICS B-LASERS AND OPTICS,124(2),27. |
| MLA | Zhou, Sheng,et al."Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection".APPLIED PHYSICS B-LASERS AND OPTICS 124.2(2018):27. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2018-2026.pdf（1576KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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