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Department薄膜光学技术研究室(十一室)
Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection
Zhou, Sheng1,2; Han, Yanling1; Li, Bincheng1,3
Source PublicationAPPLIED PHYSICS B-LASERS AND OPTICS
Volume124Issue:2Pages:27
2018-02-01
Language英语
ISSN0946-2171
DOI10.1007/s00340-018-6898-9
Indexed BySCI ; Ei
WOS IDWOS:000424352000005
EI Accession Number20180504682919
SubtypeJ
AbstractNitric oxide (NO) in exhaled breath has gained increasing interest in recent years mainly driven by the clinical need to monitor inflammatory status in respiratory disorders, such as asthma and other pulmonary conditions. Mid-infrared cavity ring-down spectroscopy (CRDS) using an external cavity, widely tunable continuous-wave quantum cascade laser operating at 5.3 mu m was employed for NO detection. The detection pressure was reduced in steps to improve the sensitivity, and the optimal pressure was determined to be 15 kPa based on the fitting residual analysis of measured absorption spectra. A detection limit (1 sigma, or one time of standard deviation) of 0.41 ppb was experimentally achieved for NO detection in human breath under the optimized condition in a total of 60 s acquisition time (2 s per data point). Diurnal measurement session was conducted for exhaled NO. The experimental results indicated that mid-infrared CRDS technique has great potential for various applications in health diagnosis.
KeywordAbsorption spectroscopy Band structure Infrared devices Nitric oxide Quantum cascade lasers
WOS KeywordNITRIC-OXIDE ; BREATH ; LASER ; AIR ; CHILDREN ; SENSOR ; GAS
EI KeywordsAbsorption spectroscopy ; Band structure ; Infrared devices ; Nitric oxide ; Quantum cascade lasers
EI Classification Number744.1 Lasers, General ; 804.2 Inorganic Compounds ; 933 Solid State Physics ; 941.4 Optical Variables Measurements
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ioe.ac.cn/handle/181551/9259
Collection薄膜光学技术研究室(十一室)
Affiliation1.Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu; Shuangliu; 610209, China;
2.Graduate University of Chinese Academy of Sciences, Beijing; 100049, China;
3.School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu; 610054, China
Recommended Citation
GB/T 7714
Zhou, Sheng,Han, Yanling,Li, Bincheng. Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection[J]. APPLIED PHYSICS B-LASERS AND OPTICS,2018,124(2):27.
APA Zhou, Sheng,Han, Yanling,&Li, Bincheng.(2018).Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection.APPLIED PHYSICS B-LASERS AND OPTICS,124(2),27.
MLA Zhou, Sheng,et al."Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection".APPLIED PHYSICS B-LASERS AND OPTICS 124.2(2018):27.
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