Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging
Lu, Mindan1; Kang, Ning2; Chen, Chuan3; Yang, Liuqing1; Li, Yang4; Hong, Minghui5; Luo, Xiangang4; Ren, Lei2,6; Wang, Xiumin1
2017
发表期刊Nanotechnology
ISSN0957-4484
卷号28期号:44页码:445710
摘要Near-infrared (NIR) triggered cyanine dyes have attracted considerable attention in multimodal tumor theranostics. However, NIR cyanine dyes used in tumor treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting in inadequate diagnostic and therapy efficacy for tumors. It is still a great challenge to improve both the photodynamic therapy (PDT) and fluorescent imaging (FLI) efficacy of cyanine dyes in tumor applications. Herein, a novel multifunctional nanoagent AuNRs@SiO2-IR795 was developed to realize the integrated photothermal/photodynamic therapy (PTT/PDT) and FLI at a very low dosage of IR795 (0.4 μM) based on metal-enhanced fluorescence (MEF) effects. In our design, both the fluorescence intensity and reactive oxygen species of AuNRs@SiO2-IR795 nanocomposites were significantly enhanced up to 51.7 and 6.3 folds compared with free IR795, owing to the localized surface plasmon resonance band of AuNRs overlapping with the absorption or fluorescence emission band of the IR795 dye. Under NIR laser irradiation, the cancer cell inhibition efficiency in vitro with synergetic PDT/PTT was up to 82.3%, compared with 10.3% for free IR795. Moreover, the enhanced fluorescence intensity of our designed nanocomposites was helpful to track their behavior in tumor cells. Therefore, our designed nanoagents highlight the applications of multimodal diagnostics and therapy in tumors based on MEF. © 2017 IOP Publishing Ltd.
关键词Diagnosis - Efficiency - Fluorescence - Gas generators - Infrared devices - Medicine - Nanocomposites - Nanorods - Plasmons - Silica - Surface plasmon resonance - Tumors
收录类别SCI ; Ei
语种英语
文献类型期刊论文
条目标识符http://ir.ioe.ac.cn/handle/181551/8846
专题微细加工光学技术国家重点实验室(开放室)
作者单位1.School of Pharmaceutical Sciences, Xiamen University, Xiamen; 361102, China;
2.Department of Biomaterials, College of Materials, Xiamen University, Xiamen; 361005, China;
3.Department of Pharmacy, Xiamen Medical College, Xiamen; 361102, China;
4.State Key Laboratory of Optical Technologies for Nano-Fabrication and Micro-Engineering, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu; 610209, China;
5.Department of Electrical and Computer Engineering, National University of Singapore, Engineering Drive 3, Singapore; 117576, Singapore;
6.State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen; 361005, China
推荐引用方式
GB/T 7714
Lu, Mindan,Kang, Ning,Chen, Chuan,et al. Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging[J]. Nanotechnology,2017,28(44):445710.
APA Lu, Mindan.,Kang, Ning.,Chen, Chuan.,Yang, Liuqing.,Li, Yang.,...&Wang, Xiumin.(2017).Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging.Nanotechnology,28(44),445710.
MLA Lu, Mindan,et al."Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging".Nanotechnology 28.44(2017):445710.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2017-2086.pdf(2232KB)期刊论文出版稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lu, Mindan]的文章
[Kang, Ning]的文章
[Chen, Chuan]的文章
百度学术
百度学术中相似的文章
[Lu, Mindan]的文章
[Kang, Ning]的文章
[Chen, Chuan]的文章
必应学术
必应学术中相似的文章
[Lu, Mindan]的文章
[Kang, Ning]的文章
[Chen, Chuan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。