| Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging | |
| Lu, Mindan1; Kang, Ning2; Chen, Chuan3; Yang, Liuqing1; Li, Yang4; Hong, Minghui5; Luo, Xiangang4; Ren, Lei2,6; Wang, Xiumin1 | |
| 2017 | |
| 发表期刊 | Nanotechnology
 |
| ISSN | 0957-4484 |
| 卷号 | 28期号:44页码:445710 |
| 摘要 | Near-infrared (NIR) triggered cyanine dyes have attracted considerable attention in multimodal tumor theranostics. However, NIR cyanine dyes used in tumor treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting in inadequate diagnostic and therapy efficacy for tumors. It is still a great challenge to improve both the photodynamic therapy (PDT) and fluorescent imaging (FLI) efficacy of cyanine dyes in tumor applications. Herein, a novel multifunctional nanoagent AuNRs@SiO2-IR795 was developed to realize the integrated photothermal/photodynamic therapy (PTT/PDT) and FLI at a very low dosage of IR795 (0.4 μM) based on metal-enhanced fluorescence (MEF) effects. In our design, both the fluorescence intensity and reactive oxygen species of AuNRs@SiO2-IR795 nanocomposites were significantly enhanced up to 51.7 and 6.3 folds compared with free IR795, owing to the localized surface plasmon resonance band of AuNRs overlapping with the absorption or fluorescence emission band of the IR795 dye. Under NIR laser irradiation, the cancer cell inhibition efficiency in vitro with synergetic PDT/PTT was up to 82.3%, compared with 10.3% for free IR795. Moreover, the enhanced fluorescence intensity of our designed nanocomposites was helpful to track their behavior in tumor cells. Therefore, our designed nanoagents highlight the applications of multimodal diagnostics and therapy in tumors based on MEF. © 2017 IOP Publishing Ltd. |
| 关键词 | Diagnosis - Efficiency - Fluorescence - Gas generators - Infrared devices - Medicine - Nanocomposites - Nanorods - Plasmons - Silica - Surface plasmon resonance - Tumors |
| 收录类别 | SCI ; Ei |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ioe.ac.cn/handle/181551/8846 |
| 专题 | 微细加工光学技术国家重点实验室（开放室） |
| 作者单位 | 1.School of Pharmaceutical Sciences, Xiamen University, Xiamen; 361102, China; 2.Department of Biomaterials, College of Materials, Xiamen University, Xiamen; 361005, China; 3.Department of Pharmacy, Xiamen Medical College, Xiamen; 361102, China; 4.State Key Laboratory of Optical Technologies for Nano-Fabrication and Micro-Engineering, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu; 610209, China; 5.Department of Electrical and Computer Engineering, National University of Singapore, Engineering Drive 3, Singapore; 117576, Singapore; 6.State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen; 361005, China |
| 推荐引用方式 GB/T 7714 | Lu, Mindan,Kang, Ning,Chen, Chuan,et al. Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging[J]. Nanotechnology,2017,28(44):445710. |
| APA | Lu, Mindan.,Kang, Ning.,Chen, Chuan.,Yang, Liuqing.,Li, Yang.,...&Wang, Xiumin.(2017).Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging.Nanotechnology,28(44),445710. |
| MLA | Lu, Mindan,et al."Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging".Nanotechnology 28.44(2017):445710. |
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| 2017-2086.pdf（2232KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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