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Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations
Liao, Meng; Zhao, Haoxing; Liu, Longqian; Li, Qian; Dai, Yun; Zhang, Yudong; Zhou, Yifeng
Source PublicationSCIENTIFIC REPORTS
Volume6
2016
Language英语
ISSN2045-2322
DOI10.1038/srep35702
Indexed BySCI
WOS IDWOS:000385585100001
SubtypeJ
AbstractPerceptual learning is considered a potential treatment for amblyopia even in adult patients who have progressed beyond the critical period of visual development because adult amblyopes retain sufficient visual plasticity. When perceptual learning is performed with the correction of high-order aberrations (HOAs), a greater degree of neural plasticity is present in normal adults and those with highly aberrated keratoconic eyes. Because amblyopic eyes show more severe HOAs than normal eyes, it is interesting to study the effects of HOA-corrected visual perceptual learning in amblyopia. In the present study, we trained twenty-six older child and adult anisometropic amblyopes while their HOAs were corrected using a real-time closed-loop adaptive optics perceptual learning system (AOPL). We found that adaptive optics (AO) correction improved the modulation transfer functions (MTFs) and contrast sensitivity functions (CSFs) of older children and adults with anisometropic amblyopia. When perceptual learning was performed with AO correction of the ocular HOAs, the improvements in visual function were not only demonstrated in the condition with AO correction but were also maintained in the condition without AO correction. Additionally, the learning effect with AO correction was transferred to the untrained visual acuity and fellow eyes in the condition without AO correction.
KeywordWave-front Aberrations Anisometropic Amblyopia Juvenile Amblyopia Visual Performance Adaptive Optics Adult Amblyopia Defined Letters Vision Eyes Acuity
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Document Type期刊论文
Identifierhttp://ir.ioe.ac.cn/handle/181551/8457
Collection自适应光学技术研究室(八室)
Affiliation1.[Liao, Meng
2.Liu, Longqian
3.Li, Qian] Sichuan Univ, West China Hosp, Dept Optometry & Visual Sci, Chengdu, Peoples R China
4.[Liao, Meng
5.Liu, Longqian
6.Li, Qian] Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu 610041, Peoples R China
7.[Zhao, Haoxing
8.Dai, Yun
9.Zhang, Yudong] Chinese Acad Sci, Inst Opt & Elect, Chengdu, Peoples R China
10.[Zhao, Haoxing
11.Dai, Yun
12.Zhang, Yudong] Chinese Acad Sci, Key Lab Adapt Opt, Chengdu 610209, Peoples R China
13.[Zhou, Yifeng] Univ Sci & Technol China, CAS Key Lab Brain Funct & Dis, Hefei 230027, Peoples R China
14.[Zhou, Yifeng] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
Recommended Citation
GB/T 7714
Liao, Meng,Zhao, Haoxing,Liu, Longqian,et al. Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations[J]. SCIENTIFIC REPORTS,2016,6.
APA Liao, Meng.,Zhao, Haoxing.,Liu, Longqian.,Li, Qian.,Dai, Yun.,...&Zhou, Yifeng.(2016).Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations.SCIENTIFIC REPORTS,6.
MLA Liao, Meng,et al."Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations".SCIENTIFIC REPORTS 6(2016).
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