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A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma
W. Zhou; Y.Y. Ma; H. Yang
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
Issue6Pages:381-386
2011
Language英语
Subtype期刊论文
AbstractBy using triangular silver (Ag) nanoparticle array, a localized surface plasmon resonance (LSPR) nanosensor was fabricated and shown to sense serum p53 protEin in vitro, which is involved in head and neck squamous cell carcinoma (HNSCC). The nanosensor consists of a triangular Ag nanoparticles array with single particle dimension of 120 nm in-plane width and 45 nm out-of-plane hEight. When examined using LSPR nanobiosensor, the results indicated significant difference in LSPR shifts (Δλmax) between HNSCC patient and control. Although there is need for precise quantification and large-scale prospective, this report shows that the LSPR nanobiosensor provides a promising platform with attractive advantages for serological diagnosis or molecular diagnosis in tumor, such as HNSCC. This is the first clinical application of the LSPR nanosensor in HNSCC.; By using triangular silver (Ag) nanoparticle array, a localized surface plasmon resonance (LSPR) nanosensor was fabricated and shown to sense serum p53 protEin in vitro, which is involved in head and neck squamous cell carcinoma (HNSCC). The nanosensor consists of a triangular Ag nanoparticles array with single particle dimension of 120 nm in-plane width and 45 nm out-of-plane hEight. When examined using LSPR nanobiosensor, the results indicated significant difference in LSPR shifts (Δλmax) between HNSCC patient and control. Although there is need for precise quantification and large-scale prospective, this report shows that the LSPR nanobiosensor provides a promising platform with attractive advantages for serological diagnosis or molecular diagnosis in tumor, such as HNSCC. This is the first clinical application of the LSPR nanosensor in HNSCC.
Document Type期刊论文
Identifierhttp://ir.ioe.ac.cn/handle/181551/6753
Collection微细加工光学技术国家重点实验室(开放室)
Corresponding AuthorW. Zhou
Affiliation中国科学院光电技术研究所
Recommended Citation
GB/T 7714
W. Zhou,Y.Y. Ma,H. Yang. A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2011(6):381-386.
APA W. Zhou,Y.Y. Ma,&H. Yang.(2011).A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma.INTERNATIONAL JOURNAL OF NANOMEDICINE(6),381-386.
MLA W. Zhou,et al."A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma".INTERNATIONAL JOURNAL OF NANOMEDICINE .6(2011):381-386.
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