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题名:
A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma
作者: Zhou, Wei; Ma, Yingyi; Yang, Huan2; Ding, Yi1; Luo, Xiangang2
刊名: INTERNATIONAL JOURNAL OF NANOMEDICINE
出版日期: 2011
卷号: 6, 页码:381-386
关键词: localized surface plasmon resonance ; p53 protein ; biosensor ; oral squamous-cell carcinoma
文章类型: Article
英文摘要: By using triangular silver (Ag) nanoparticle array, a localized surface plasmon resonance (LSPR) nanosensor was fabricated and shown to sense serum p53 protein in vitro, which is involved in head and neck squamous cell carcinoma (HNSCC). The nanosensor consists of a triangular Ag nanoparticles array with single particle dimension of 120 nm in-plane width and 45 nm out-of-plane height. When examined using LSPR nanobiosensor, the results indicated significant difference in LSPR shifts (Delta lambda(max)) between HNSCC patient and control. Although there is need for precise quantification and large-scale prospective, this report shows that the LSPR nanobiosensor provides a promising platform with attractive advantages for serological diagnosis or molecular diagnosis in tumor, such as HNSCC. This is the first clinical application of the LSPR nanosensor in HNSCC.
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]: Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]: PROTEIN ; ANTIGEN
收录类别: SCI
语种: 英语
WOS记录号: WOS:000288248900040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ioe.ac.cn/handle/181551/3463
Appears in Collections:光电技术研究所被WoS收录文章_期刊论文

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作者单位: 1.Sichuan Univ, W China Coll Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Inst Opt & Elect, State Key Lab Opt Technol Microfabricat, Chengdu, Peoples R China

Recommended Citation:
Zhou, Wei,Ma, Yingyi,Yang, Huan,et al. A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2011,6:381-386.
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