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题名:
Clinical application of a novel sliver nanoparticles biosensor based on localized surface plasmon resonance for detecting the microalbuminuria
作者: Lai, Ting1; Hou, Qiannan1; Yang, Huan2; Luo, Xiangang2; Xi, Mingrong1
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期: 2010-11-01
卷号: 42, 期号:11, 页码:787-792
关键词: localized surface plasmon resonance (LSPR) ; biosensor ; microalbuminuria
文章类型: Article
英文摘要: In order to explore the clinical application of the nanobiosensor based on localized surface plasmon resonance (LSPR), we used our LSPR biosensor to detect the microalbuminuria in this work. The sliver nanoparticles were fabricated by using nanosphere lithography. The anti-human albumin antibody was immobilized on the sensor surface by amine coupling method. The different concentrations of commercial albumin and albumin in urine samples from three mild preeclampsia patients were determined according to the peak of LSPR extinction spectra. Under optimum conditions, our results showed that the biosensor displayed a detection limit of 1 ng/ml and wide dynamic range of 1 ng/ml to 1 mu g/ml. Furthermore, the microalbuminuria of three patients was determined by our biosensor within a short assay time, without sample purification. This biosensor proposed herein is easy to prepare and could be used for low-cost, rapid, label-free, and sensitive screening of the microalbuminuria. This approach provides a promising platform for developing clinical diagnostic applications.
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NANOSCALE OPTICAL BIOSENSOR ; CARDIOVASCULAR EVENTS ; ALZHEIMERS-DISEASE ; REAL-TIME ; ALBUMINURIA ; BINDING ; RISK ; DEPENDENCE ; MORTALITY ; ASSAY
收录类别: SCI
语种: 英语
WOS记录号: WOS:000283657600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ioe.ac.cn/handle/181551/3358
Appears in Collections:光电技术研究所被WoS收录文章_期刊论文

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作者单位: 1.Sichuan Univ, W China Univ Hosp 2, Dept Gynecol & Obstet, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Inst Opt & Elect, State Key Lab Opt Technol Microfabricat, Chengdu 610209, Peoples R China

Recommended Citation:
Lai, Ting,Hou, Qiannan,Yang, Huan,et al. Clinical application of a novel sliver nanoparticles biosensor based on localized surface plasmon resonance for detecting the microalbuminuria[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(11):787-792.
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