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题名:
Influence of Cr Adhesion Layer on Detection of Amyloid-Derived Diffusible Ligands Based on Localized Surface Plasmon Resonance
作者: Zhu, Shaoli1; Du, ChunLei1; Fu, Yongqi2; Deng, Qiling1; Shi, Lifang1
刊名: PLASMONICS
出版日期: 2009-06-01
卷号: 4, 期号:2, 页码:135-140
关键词: LSPR ; ADDLs ; Anti-ADDL ; Passivation ; Cr adhesion layer
文章类型: Article
英文摘要: A Cr adhesion layer inserted between Ag nanoparticles and a glass substrate, for the purpose of improving the adhesion of Ag nanoparticles to glass, was observed to cause an abnormal peak shift of extinction spectra in non-specific reactions. The undesired peak shift misleads molecule detection in non-specific reactions. To solve this issue, a practical technique using n-propyl-trimethoxysilane-based passivation for the detection of amyloid-derived diffusible ligands was investigated as a route to eliminate the abnormal peak shifting observed in the non-specific reactions. To evaluate this passivation technique, localized surface plasmon resonance immunoassay experiments were conducted. Experimental results derived with and without the passivation process were investigated as a basis for comparative analysis. Our experimental results demonstrate that this passivation technique effectively eliminates the observed peak shift originating from the Cr adhesion layer.
WOS标题词: Science & Technology ; Physical Sciences ; Technology
类目[WOS]: Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: NANOSCALE OPTICAL BIOSENSOR ; SELF-ASSEMBLED MONOLAYERS ; ALZHEIMERS-DISEASE ; SILVER NANOPARTICLES ; SPECTROSCOPY ; A-BETA(1-42) ; NEUROTOXINS ; DEPENDENCE ; OLIGOMERS
收录类别: SCI
语种: 英语
WOS记录号: WOS:000266390000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ioe.ac.cn/handle/181551/3292
Appears in Collections:光电技术研究所被WoS收录文章_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Opt & Elect, State Key Lab Opt Technol Microfabricat, Chengdu 610209, Peoples R China
2.Univ Elect Sci & Technol China, Sch Phys Elect, Chengdu 610054, Peoples R China

Recommended Citation:
Zhu, Shaoli,Du, ChunLei,Fu, Yongqi,et al. Influence of Cr Adhesion Layer on Detection of Amyloid-Derived Diffusible Ligands Based on Localized Surface Plasmon Resonance[J]. PLASMONICS,2009,4(2):135-140.
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