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题名:
Light-directed migration of D. discoideum slugs in microfabricated confinements
作者: Kim, Jinho1; Ennis, Herbert L.2; Thai Huu Nguyen1; Zhuang, Xuye4; Luo, Ji4; Yao, Jun4; Kessin, Richard H.3; Stojanovic, Milan2; Lin, Qiao1
刊名: SENSORS AND ACTUATORS A-PHYSICAL
出版日期: 2012-12-01
卷号: 188, 页码:312-319
关键词: Bio-microactuator ; Microorganism ; Dictyostelium discoideum ; Microchannel ; Phototaxis
文章类型: Article
英文摘要: This paper investigates the light-driven migration of the multi-cellular microorganism Dictyostelium discoideum as a potential bio-actuation mechanism in microsystems. As a platform for slug migration we use microscale confinements, which consist of intersecting microchannels fabricated from solidified agar-water solution. The agar surface provides necessary moisture to the slugs during the experiment while remaining sufficiently stiff to allow effective slug migration. The movements of the slugs in the microchannels are driven and guided by phototaxis via controlling light transmitted through optical fibers. The microchannels impose geometrical confinements on the migrating slugs, improving the spatial precision of the migration. We demonstrate that slugs that form in a microchamber can be driven to migrate through the microchannels, as well as steered to a particular direction at microchannel intersections. Our experimental results indicate that slug movements can be more effectively controlled in microchannels, and potentially useful for bio-actuation applications. (C) 2012 Elsevier B.V. All rights reserved.
WOS标题词: Science & Technology ; Technology
类目[WOS]: Engineering, Electrical & Electronic ; Instruments & Instrumentation
研究领域[WOS]: Engineering ; Instruments & Instrumentation
关键词[WOS]: DICTYOSTELIUM-DISCOIDEUM ; THERMOTAXIS ; PHOTOTAXIS ; MOVEMENT
收录类别: SCI ; ISTP
语种: 英语
WOS记录号: WOS:000312692500042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ioe.ac.cn/handle/181551/2411
Appears in Collections:光电技术研究所被WoS收录文章_期刊论文

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作者单位: 1.Columbia Univ, Dept Mech Engn, New York, NY 10027 USA
2.Columbia Univ, Div Clin Pharmacol & Expt Therapeut, Dept Med, New York, NY 10032 USA
3.Columbia Univ, Dept Anat & Cell Biol, New York, NY 10032 USA
4.Chinese Acad Sci, Inst Opt & Elect, Chengdu 610209, Peoples R China

Recommended Citation:
Kim, Jinho,Ennis, Herbert L.,Thai Huu Nguyen,et al. Light-directed migration of D. discoideum slugs in microfabricated confinements[J]. SENSORS AND ACTUATORS A-PHYSICAL,2012,188:312-319.
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