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Light-directed migration of D. discoideum slugs in microfabricated confinements
Kim, Jinho1; Ennis, Herbert L.2; Thai Huu Nguyen1; Zhuang, Xuye4; Luo, Ji4; Yao, Jun4; Kessin, Richard H.3; Stojanovic, Milan2; Lin, Qiao1
Source PublicationSENSORS AND ACTUATORS A-PHYSICAL
Volume188Pages:312-319
2012-12-01
Language英语
Indexed BySCI ; ISTP
WOS IDWOS:000312692500042
SubtypeArticle
AbstractThis paper investigates the light-driven migration of the multi-cellular microorganism Dictyostelium discoideum as a potential bio-actuation mechanism in microsystems. As a platform for slug migration we use microscale confinements, which consist of intersecting microchannels fabricated from solidified agar-water solution. The agar surface provides necessary moisture to the slugs during the experiment while remaining sufficiently stiff to allow effective slug migration. The movements of the slugs in the microchannels are driven and guided by phototaxis via controlling light transmitted through optical fibers. The microchannels impose geometrical confinements on the migrating slugs, improving the spatial precision of the migration. We demonstrate that slugs that form in a microchamber can be driven to migrate through the microchannels, as well as steered to a particular direction at microchannel intersections. Our experimental results indicate that slug movements can be more effectively controlled in microchannels, and potentially useful for bio-actuation applications. (C) 2012 Elsevier B.V. All rights reserved.
KeywordBio-microactuator Microorganism Dictyostelium Discoideum Microchannel Phototaxis
WOS KeywordDICTYOSTELIUM-DISCOIDEUM ; THERMOTAXIS ; PHOTOTAXIS ; MOVEMENT
WOS Research AreaEngineering ; Instruments & Instrumentation
WOS SubjectEngineering, Electrical & Electronic ; Instruments & Instrumentation
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Document Type期刊论文
Identifierhttp://ir.ioe.ac.cn/handle/181551/2411
Collection光电技术研究所被WoS收录文章
Affiliation1.Columbia Univ, Dept Mech Engn, New York, NY 10027 USA
2.Columbia Univ, Div Clin Pharmacol & Expt Therapeut, Dept Med, New York, NY 10032 USA
3.Columbia Univ, Dept Anat & Cell Biol, New York, NY 10032 USA
4.Chinese Acad Sci, Inst Opt & Elect, Chengdu 610209, Peoples R China
Recommended Citation
GB/T 7714
Kim, Jinho,Ennis, Herbert L.,Thai Huu Nguyen,et al. Light-directed migration of D. discoideum slugs in microfabricated confinements[J]. SENSORS AND ACTUATORS A-PHYSICAL,2012,188:312-319.
APA Kim, Jinho.,Ennis, Herbert L..,Thai Huu Nguyen.,Zhuang, Xuye.,Luo, Ji.,...&Lin, Qiao.(2012).Light-directed migration of D. discoideum slugs in microfabricated confinements.SENSORS AND ACTUATORS A-PHYSICAL,188,312-319.
MLA Kim, Jinho,et al."Light-directed migration of D. discoideum slugs in microfabricated confinements".SENSORS AND ACTUATORS A-PHYSICAL 188(2012):312-319.
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