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题名:
Formation and Stimuli-Directed Migration of D. discoideum Slugs in Microchips
作者: Kim, Jinho1; Olsen, Timothy1; Zhuang, Xuye2; Luo, Ji2; Yao, Jun2; Stojanovic, Milan3; Lin, Qiao1
刊名: JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
出版日期: 2013
卷号: 33, 期号:3, 页码:263-268
关键词: Microfluidic device ; Microorganism ; Dictyostelium discoideum ; Phototaxis ; Thermotaxis ; Bio-microactuator
文章类型: Article
英文摘要: This paper presents a microfluidic device that geometrically constrains the development of individual Dictyostelium discoideum cells into multicellular organisms (slugs). A microchip for the stimuli-directed migration of slugs is also presented. To demonstrate the formation of slugs in a predetermined shape, a microchip is designed to confine the slugs in the vertical direction. In the microchip, sufficient oxygen is supplied to the cells via a membrane, allowing the formation and adaptation of slugs to the shape of the channel In addition, the manipulation of slug migration direction in a microchip via external stimuli, such as light and temperature gradients, that induce phototaxis and thermotaxis of slugs, respectively, is demonstrated. To direct slug migration with external stimuli, an optical fiber is used for phototaxis and an electrical wire heater is used for thermotaxis. Experimental results show slug formation in a predefined geometry in the microchip, suggesting that this chip is potentially useful for understanding the relationship between the shape and function of cells or tissue. The controlled migration of slugs demonstrated in the microchips can potentially be employed in biologically based microactuators or microrobots.
WOS标题词: Science & Technology ; Technology
类目[WOS]: Engineering, Biomedical
研究领域[WOS]: Engineering
关键词[WOS]: DICTYOSTELIUM-DISCOIDEUM ; CULTURE ; ARRAY
收录类别: SCI
语种: 英语
WOS记录号: WOS:000322734800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ioe.ac.cn/handle/181551/1208
Appears in Collections:光电技术研究所被WoS收录文章_期刊论文

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作者单位: 1.Columbia Univ, Dept Mech Engn, New York, NY 10027 USA
2.Chinese Acad Sci, Inst Opt & Elect, Chengdu 610209, Peoples R China
3.Columbia Univ, Dept Med, Div Clin Pharmacol & Expt Therapeut, New York, NY 10032 USA

Recommended Citation:
Kim, Jinho,Olsen, Timothy,Zhuang, Xuye,et al. Formation and Stimuli-Directed Migration of D. discoideum Slugs in Microchips[J]. JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,2013,33(3):263-268.
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